Research article summary (published 30 Dec 1995):

[An in-vitro leukocytolysis method for the diagnosis of a drug allergy]

(Metod leikotsitoliza in vitro dlia diagnostiki lekarstvennoi allergii.)

Full Abstract

The authors analyze published data on various modifications of the specific leukocyte lysis test (SLLT) and their own findings on in vitro osmotic leukocytolysis caused by low-molecular nonelectrolytes (urea, glycerol, and glucose), and present the estimation of osmotic pressure of these agents' solutions in equimolar concentrations. In contrast to the specific effect of allergens, an osmotic component of nonspecific leukocyte lysis is considered. A universal approach to the choice of working doses of drug in SLLT is proposed: equimolar solutions of the allergens (chemical and medicinal compounds). The necessity of further theoretical and practical research of SLLT is validated.

Author information

Author/s: Vavilov, M P (MP); Kiselev, A S (AS); Nazarova, E K (EK);

Journal and publication information

Publication Type: Comparative Study; English Abstract; Journal Article

Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn), published in RUSSIA. (Language: rus)

Reference: -1996 Jan-Feb; vol (issue 1) : pp 44-7

Dates: Created 1996/10/09; Completed 1996/10/09; Revised 2006/11/15;

PMID: 8775794, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Allergens - diagnostic use Dose-Response Relationship, Drug Drug Hypersensitivity - diagnosis Humans Immunologic Tests - methods

Immunologic Tests - methods Leukocytes - drug effects Molecular Weight Osmotic Pressure Solutions

Associated Chemicals: Allergens (0) ; Solutions (0)

Related articles

These are the highest related articles currently in the database:

• [Modification of the specific lysis reaction of leukocytes in vitro for studying sensitization of chemical and drug etiology] 30 Jan 1978
• Relationship between antigen induced histamine release and cyclic AMP level in human leukocytes. 30 Jul 1974
• [Use of the leukocytolysis reaction for studying sensitization to drug preparations] 30 Dec 1981
• Latex, an intriguing allergen. 29 Apr 1995
• [Determination of the hyperergic state of the body to E. coli] 30 Dec 1985
• [Choice of doses of chemical substances for allergodiagnosis in vitro] 30 Dec 1976
• Changes in histamine and cyclic nucleotide levels after bronchoprovocation in patients with extrinsic asthma. 30 Dec 1977
• Immunotherapy in spring-time hay fever. A clinical and immunological study comparing two different treatment extract compositions. 30 Jul 1979
• [Drug allergy in nurses] 30 Mar 1979
• Occupational allergy in nurses to a bulk laxative. 30 Jan 1979

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.