Research article summary (published 30 May 1996):

Pharmacokinetic aspects of rectal formulations of temazepam.

Full Abstract

An in vitro/in vivo study was carried out with different rectal formulations of temazepam. Pharmacokinetic data were determined in a cross-over study in 10 volunteers after rectal administration of 10 mg temazepam as a polyethylene glycol based suppository (selected from in vitro data), a liquid-filled capsule and a micro-enema respectively, using oral administration of a liquid-filled capsule as a reference. Serum levels of temazepam indicate an instantaneous and complete release from the micro-enema (Frel = 0.94 +/- 0.21, Cmax 205 +/- 36.9 micrograms/l, tmax 0.49 +/- 0.31 hour) and a slower but complete release of temazepam from the suppository (Frel = 1.10 +/- 0.25, Cmax 202 +/- 41.3 micrograms/l, tmax 1.48 +/- 0.41 hour). A high interindividual variation in absorption profiles was observed after rectal administration of the liquid-filled capsule (Frel 0.72 +/- 0.36, Cmax 182 +/- 122 micrograms/l, tmax 4.08 +/- 4.28 hour), which makes it less suitable for rectal use. The micro-enema and suppository appear to be useful as rectal formulations for temazepam.

Author information

Author/s: Hanff, L M (LM); Rutten, W J (WJ);

Affiliation: Department of Pharmacy, University Hospital Rotterdam, The Netherlands.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Pharmacy world & science : PWS (Pharm World Sci), published in NETHERLANDS. (Language: eng)

Reference: 1996-Jun; vol 18 (issue 3) : pp 114-9

Dates: Created 1997/04/02; Completed 1997/04/02; Revised 2006/11/15;

PMID: 8826537, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Administration, Rectal Adult Anti-Anxiety Agents - administration & dosage; pharmacokinetics Area Under Curve Capsules Excipients Half-Life Humans

Humans Male Metabolic Clearance Rate Middle Aged Polyethylene Glycols Solutions Suppositories Temazepam - administration & dosage; pharmacokinetics

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Anti-Anxiety Agents (0) ; Capsules (0) ; Excipients (0) ; Polyethylene Glycols (0) ; Solutions (0) ; Suppositories (0) ; Temazepam (846-50-4)

Related articles

These are the most related articles currently in our database:

• A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population. 30 Aug 1997
• Pharmacokinetics of a new sublingual formulation of temazepam. 30 Dec 1987
• Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. 29 Nov 2003
• Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam. 30 Mar 1989
• A methodological comparison of two formulations of temazepam in pharmacokinetic and pharmacodynamic aspects. 30 Dec 1988
• Premedication with temazepam in minor surgery. The relationship between plasma concentration and clinical effect after a dose of 40 mg. 29 Sep 1989
• Efficacy of activated charcoal versus gastric lavage half an hour after ingestion of moclobemide, temazepam, and verapamil. 29 Jun 2000
• Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects. 31 Mar 2005
• Plasma and cerebrospinal fluid concentration of temazepam following oral drug administration. 30 Dec 1989

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a larger map of 100+ related articles.