Research article summary (published 30 Oct 1996):

Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex.

Full Abstract

The prefrontal cortex has often been implicated in the pathophysiology of schizophrenia. Schizophrenic patients are known to suffer from certain information processing deficits, which can be detected, among others, in the prepulse inhibition and the latent inhibition paradigm. The present study was designed to investigate the role of dopamine receptors in the medial prefrontal cortex in prepulse inhibition and latent inhibition. The results show that the local application of the selective antagonist of the dopamine D1-like receptor family, SCH 39166, into the medial prefrontal cortex dose-dependently reduced prepulse inhibition. Likewise, the selective antagonist of the dopamine D2-like receptor family, sulpiride, injected into the medial prefrontal cortex dose-dependently reduced prepulse inhibition. Neither of these antagonists, however, influenced latent inhibition as measured with the conditioned taste aversion paradigm. These data further indicate that the neuronal substrates of latent inhibition and prepulse inhibition are clearly different. Since the prefrontal cortex is intimately related to subcortical dopamine, the possible differential involvement of subcortical dopaminergic terminal fields in prepulse inhibition and latent inhibition is discussed.

Author information

Author/s: Ellenbroek, B A (BA); Budde, S (S); Cools, A R (AR);

Journal and publication information

Publication Type: Journal Article

Journal: Neuroscience (Neuroscience), published in UNITED STATES. (Language: eng)

Reference: 1996-Nov; vol 75 (issue 2) : pp 535-42

Dates: Created 1997/03/14; Completed 1997/03/14; Revised 2003/11/14;

PMID: 8931016, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Avoidance Learning - drug effects Benzazepines - administration & dosage; pharmacology Dopamine - physiology Dopamine Antagonists - pharmacology Drinking Behavior - drug effects Evoked Potentials - physiology Injections Male

Prefrontal Cortex - drug effects; physiology Rats Rats, Wistar Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D2 - antagonists & inhibitors Startle Reaction - drug effects; physiology Sulpiride - administration & dosage; pharmacology Synaptic Transmission - drug effects Taste - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Benzazepines (0) ; Dopamine Antagonists (0) ; Receptors, Dopamine D1 (0) ; Receptors, Dopamine D2 (0) ; Sch 39166 (112108-01-7) ; Sulpiride (15676-16-1) ; Dopamine (51-61-6)

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