Research article summary (published 29 Nov 1996):

CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon.

Full Abstract

CP-135,807 [3-(N-methylpyrrolidin-2R-ylmethyl)-5-(3-nitropyrid-2- yl)amino-1H-indole] binds with high affinity to central 5-HT1D receptors, and in functional studies produces dose-dependent decreases in extracellular serotonin. These and other findings have suggested that CP-135,807 may act as a terminal 5-HT autoreceptor agonist. In an attempt to characterize the behavioral activity of selective 5-HT1D ligands, adult male Carneau pigeons were trained to discriminate IM injections of 0.1 mg/kg CP-135,807 from saline under a two-key, fixed ratio schedule of food-reinforced key pecking. CP-135,807 and the structurally unrelated 5-HT1D agonist CP-286,601 fully and dose-dependently substituted for the training dose. In contrast, little substitution was observed following administration of 8-OH-DPAT, a potent 5-HT1A agonist, the 5-HT1B agonist CP-94,253, or the serotonin reuptake inhibitor sertraline. In addition, the discriminative stimulus produced by CP-135,807 was not blocked by WAY 100,635, a selective 5-HT1A antagonist, but was completely and dose-dependently antagonized by the selective 5-HT1D antagonist, GR 127935. In subjects trained under a multiple schedule of punished and unpunished responding, 8-OH-DPAT produced large increases in punished responding while having little effect on unpunished responding. In contrast, CP-135,807 and CP-94,253 produced no antipunishment effects, while GR 127935 produced modest increases in punished responding. Collectively, these results suggest that CP-135,807 produces centrally mediated psychoactive effects that differ distinctly from those of 5-HT1A agonists.

Author information

Author/s: Mansbach, R S (RS); Rovetti, C C (CC); Macor, J E (JE);

Affiliation: Department of Neuroscience, Pfizer Central Research, Groton, CT 06340, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in GERMANY. (Language: eng)

Reference: 1996-Dec; vol 128 (issue 3) : pp 313-9

Dates: Created 1997/03/24; Completed 1997/03/24; Revised 2004/11/17;

PMID: 8972551, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Behavior, Animal - drug effects Columbidae Conditioning, Operant - drug effects Discrimination (Psychology) - drug effects Discrimination Learning - drug effects Dose-Response Relationship, Drug Indoles - antagonists & inhibitors; pharmacology

Indoles - antagonists & inhibitors; pharmacology Male Oxadiazoles - pharmacology Piperazines - pharmacology Punishment Pyridines - antagonists & inhibitors; pharmacology Receptors, Serotonin - physiology Serotonin Agonists - pharmacology Serotonin Antagonists - pharmacology

Associated Chemicals: Indoles (0) ; Oxadiazoles (0) ; Piperazines (0) ; Pyridines (0) ; Receptors, Serotonin (0) ; Serotonin Agonists (0) ; Serotonin Antagonists (0) ; WAY 100635 (146714-97-8) ; GR 127935 (148672-13-3) ; CP 135807 (151272-90-1) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)

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