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| Research article summary (published 27 Nov 1996): |
Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification.
Full Abstract
Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells is often caused by mutations or gene amplification. Molecular analyses of the XPA genes in human ovarian cancers indicate that gene mutation and amplification are not the cause of enhanced XPA mRNA levels in ovarian cancers overexpressing XPA. Altered nucleotide excision repair (NER) gene regulation in chemoresistant tumors is discussed.
Author information
Author/s: States, J C (JC); Reed, E (E);
Affiliation: Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA.cstates(-atsign-)cmb.biosci.wayne.edu
Journal and publication information
Publication Type: Journal Article
Journal: Cancer letters (Cancer Lett), published in IRELAND. (Language: eng)
Reference: 1996-Nov; vol 108 (issue 2) : pp 233-7
Dates: Created 1997/01/09; Completed 1997/01/09; Revised 2005/11/17;
PMID: 8973600, status: MEDLINE (last retrieved date: 2/18/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Antineoplastic Agents (0) ; DNA-Binding Proteins (0) ; Neoplasm Proteins (0) ; RNA, Messenger (0) ; Tumor Suppressor Protein p53 (0) ; XPA protein, human (0) ; Xeroderma Pigmentosum Group A Protein (0) ; Cisplatin (15663-27-1)Related articles
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