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| Research article summary (published 26 Feb 1997): |
Corpus callosum size and inter-hemispheric function in schizophrenia.
Full Abstract
We studied the relationship between corpus callosum area and both inter-hemispheric facilitation and interference in schizophrenics and controls. Mid-sagittal sections through the corpus callosum were measured using structural magnetic resonance imaging on 42 patients and 43 normal controls, along with symptom profiles. In a sub-sample, a modified version of the Stroop Test was also performed (27 patients and 29 controls) to assess inter-hemispheric facilitation and interference of colour naming. In the larger sample (total subjects, n = 85), there were no significant differences between patients and controls in CC area but a trend towards smaller values in patients in all but the posterior segment. In the sub-sample, bilateral facilitation was greater, and interference, less in schizophrenics compared with controls. There was a positive correlation between facilitation and posterior CC area, parallelled by a negative correlation between interference and posterior CC area, in both patients and controls, which only reached statistical significance when both groups were combined. These findings suggest that the link, between CC size and neuropsychological processes involving inter-hemispheric transfer of information, is common to both schizophrenics and normal controls. There were significant negative correlations between anterior CC area and psychomotor poverty (avolition, anhedonia and affective flattening), and a suggestion that the negative correlation between age and CC size in controls was not present in patients.
Author information
Author/s: Woodruff, P W (PW); Phillips, M L (ML); Rushe, T (T); Wright, I C (IC); Murray, R M (RM); David, A S (AS);
Affiliation: Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Schizophrenia research (Schizophr Res), published in NETHERLANDS. (Language: eng)
Reference: 1997-Feb; vol 23 (issue 3) : pp 189-96
Dates: Created 1997/07/09; Completed 1997/07/09; Revised 2006/11/15;
PMID: 9075296, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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