Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.

Full Abstract

Effects of excitatory aminoacids (EAAs) aspartate (ASP) and glutamate (GLU) in a low (50 ng, i.c.) and high dose (20 micrograms, i.c.), were studied on nociception, catalepsy and rectal temperature in albino rats. Both ASP and GLU altered the tail flick reaction time to thermal stimulation in a dose dependent manner, increasing it with low doses and reduced with high doses. Naloxone (10 micrograms, ic) antagonized the anti-nociceptive effect of EAAs while ketamine (10 micrograms, ic)-a NMDA receptor antagonist antagonized the hyperalgesic effect. These EAAs also antagonized catalepsy induced by haloperidol, chlorpromazine, trifluoperazine and morphine. Both ASP and GLU produced a hyperthermic response in all animals, including those in which hypothermia was induced by reserpine. These EAAs produced a comparable central modulatory effects on nociception, catalepsy and core temperature.

Author information

Author/s: Singh, J (J); Gupta, M C (MC);

Affiliation: Department of Pharmacology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak.

Journal and publication information

Publication Type: Journal Article

Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol), published in INDIA. (Language: eng)

Reference: 1997-Apr; vol 41 (issue 2) : pp 123-8

Dates: Created 1997/08/18; Completed 1997/08/18; Revised 2003/11/14;

PMID: 9142555, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adrenergic Uptake Inhibitors - toxicity
Analgesia
Analgesics, Opioid - administration & dosage; toxicity
Animals
Aspartic Acid - administration & dosage; pharmacology; therapeutic use
Body Temperature - drug effects; physiology
Catalepsy - drug therapy
Chlorpromazine - administration & dosage; pharmacology
Dopamine Antagonists - administration & dosage; toxicity
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists - toxicity
Fever - chemically induced
Glutamic Acid - administration & dosage; pharmacology; therapeutic use

Glutamic Acid - administration & dosage; pharmacology; therapeutic use
Haloperidol - administration & dosage; toxicity
Hypothermia - chemically induced
Injections, Subcutaneous
Ketamine - pharmacology
Male
Morphine - administration & dosage; toxicity
Naloxone - administration & dosage; pharmacology
Narcotic Antagonists - administration & dosage; pharmacology
Nociceptors - drug effects
Rats
Reserpine - toxicity
Trifluoperazine - administration & dosage; pharmacology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Adrenergic Uptake Inhibitors (0) ; Analgesics, Opioid (0) ; Dopamine Antagonists (0) ; Excitatory Amino Acid Antagonists (0) ; Narcotic Antagonists (0) ; Trifluoperazine (117-89-5) ; Naloxone (465-65-6) ; Chlorpromazine (50-53-3) ; Reserpine (50-55-5) ; Haloperidol (52-86-8) ; Aspartic Acid (56-84-8) ; Glutamic Acid (56-86-0) ; Morphine (57-27-2) ; Ketamine (6740-88-1)

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