Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat.

Full Abstract

It has been proposed that interaction of catecholamines and indoleamines with free radicals may result in the formation of endogenous neurotoxins. In order to better understand the mechanisms involved in neurodegenerative disorders showing evidence of oxidative stress, we have studied the basal concentrations and the turnover rates of dopamine, noradrenaline, serotonin and their metabolites in the prefrontal cortex of rats that were fed on control or low selenium diets. Nutritional deficit of selenium decreases the brain antioxidant protection in experimental conditions by the decrease in glutathione peroxidase activity. The dopamine and serotonin turnover increased and noradrenaline and 5-hydroxy-3-indoleacetic acid turnover decreased compared to experimental control animals. The increase of dopamine turnover in experimental rats was accompanied by an increase in tyrosine hydroxylase activity. These results suggest that the decrease of brain protection against oxidative damage could induce brain damage by disturbing the turnover rate of some monoamines.

Author information

Author/s: Castaño, A (A); Ayala, A (A); Rodríguez-Gómez, J A (JA); Herrera, A J (AJ); Cano, J (J); Machado, A (A);

Affiliation: Departamento de Bioquimica, Bromatología y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurochemistry international (Neurochem Int), published in ENGLAND. (Language: eng)

Reference: 1997-Jun; vol 30 (issue 6) : pp 549-55

Dates: Created 1997/07/07; Completed 1997/07/07; Revised 2006/11/15;

PMID: 9152996, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Antioxidants - metabolism
Blotting, Western
Diet
Dopamine - metabolism
Female
Glutathione Peroxidase - metabolism

Associated Chemicals: Antioxidants (0) ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Homovanillic Acid (306-08-1) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6) ; Hydroxyindoleacetic Acid (54-16-0) ; Selenium (7782-49-2) ; Glutathione Peroxidase (EC 1.11.1.9)

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