Research article summary (published 30 Jul 1997):

In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza.

Full Abstract

The cytotoxicity-guided fractionation of the roots of Salvia miltiorrhiza B. (Labiatae) extracts led to the isolation of eighteen active principles 1-18, responsible for the cytotoxicity against five cultured human tumor cell lines, i.e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), using the SRB (sulfrhodamine-B) method in vitro. All active compounds 1-18 including two novel components 5 and 11 were comprised of tanshinone pigments, unusual diterpenes exclusively found in this species. The proliferation of each examined tumor cell line was significantly inhibited (IC50 values ranged from 0.2 to 8.1 micrograms/ml) during the continuous exposure of tumor cells to 1-18 for 48 hours, respectively.

Author information

Author/s: Ryu, S Y (SY); Lee, C O (CO); Choi, S U (SU);

Affiliation: Korea Research Institute of Chemical Technology, Taejeon, Korea.

Journal and publication information

Publication Type: Journal Article

Journal: Planta medica (Planta Med), published in GERMANY. (Language: eng)

Reference: 1997-Aug; vol 63 (issue 4) : pp 339-42

Dates: Created 1997/09/19; Completed 1997/09/19; Revised 2004/11/17;

PMID: 9270379, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Antineoplastic Agents, Phytogenic - chemistry; isolation & purification; pharmacology Humans Medicine, Chinese Traditional Molecular Structure

Molecular Structure Phenanthrenes - chemistry; isolation & purification; pharmacology Plants, Medicinal - chemistry Tumor Cells, Cultured

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antineoplastic Agents, Phytogenic (0) ; Phenanthrenes (0) ; tanshinone (568-73-0)

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