Unsaturated fatty acids as endogenous bioregulators.

Full Abstract

Most biological functions of unsaturated fatty acids are due to their ability to act as second messengers or modulators of activities of functionally important proteins; these functions are not related to oxidative metabolism of unsaturated fatty acids. These acids regulate the activity of phospholipases, ion channels, ATPases, G-proteins, and protein kinases; they also modulate the phosphoinositide and sphingomyelin cycles, the transfer of hormonal information, and gene transcription. The great diversity of effects of unsaturated fatty acids and their presence at the earliest stages of evolution suggest for these bioregulators a system-forming role in the living body.

Author information

Author/s: Kogteva, G S (GS); Bezuglov, V V (VV);

Affiliation: Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. vvbez(-atsign-)oxylipin.siobc.ras.ru

Journal and publication information

Publication Type: Journal Article; Review

Journal: Biochemistry. Biokhimii?a (Biochemistry (Mosc)), published in RUSSIA. (Language: eng)

Reference: 1998-Jan; vol 63 (issue 1) : pp 4-12

Dates: Created 1998/04/28; Completed 1998/04/28; Revised 2006/11/15;

PMID: 9526089, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adenosine Triphosphatases - metabolism
Animals
Fatty Acids, Unsaturated - physiology
Gene Expression Regulation
Hormones - metabolism
Humans

Associated Chemicals: Fatty Acids, Unsaturated (0) ; Hormones (0) ; Ion Channels (0) ; Phosphatidylinositols (0) ; Phospholipases (EC 3.1.-) ; Adenosine Triphosphatases (EC 3.6.1.-)

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