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| Research article summary (published 27 Feb 1998): |
Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii.
Full Abstract
Methanol extracts of 36 samples of 21 Umbelliferae plants were screened for polyacetylenic compounds using the ELISA for panaxytriol, and their antiproliferative activity was checked by MTT assay using the tumor cell lines MK-1, HeLa and B16F10. The presence of antiproliferative polyacetylenes was suggested in Angelica acutiloba (fruit), Anethum graveolens (root), Bupleurum rotundifolium (fruit), Carum carvi (fruit and root), Coriandrum sativum (fruit), Cryptotaenia japonica (leaf), Glehnia littoralis (fruit), Heracleum moellendorffii (root) and Torilis japonica (fruit). Panaxynol and falcarindiol were successfully isolated from the root of Heracleum moellendorffii as antiproliferative polyacetylenes.
Author information
Author/s: Nakano, Y (Y); Matsunaga, H (H); Saita, T (T); Mori, M (M); Katano, M (M); Okabe, H (H);
Affiliation: Faculty of Hospital Pharmacy, Saga Medical School, Nabeshima, Japan.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull), published in JAPAN. (Language: eng)
Reference: 1998-Mar; vol 21 (issue 3) : pp 257-61
Dates: Created 1998/05/28; Completed 1998/05/28; Revised 2006/11/15;
PMID: 9556156, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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