Research article summary (published 29 Apr 1998):

Antiproliferative constituents in umbelliferae plants. III. Constituents in the root and the ground part of Anthriscus sylvestris Hoffm.

Full Abstract

The MeOH extract of the root and the ground part of Anthriscus sylvestris Hoffm. showed a high inhibitory activity against MK-1, HeLa, and B16F10 cell growth in vitro. The activity was found only in the CHCI3-soluble fractions. From the CHCI3-soluble fraction of the root, falcarindiol, 1-(3'-methoxy-4',5'-methylenedioxyphenyl)-1 xi-methoxy-2-propene, elemicin, and nemerosin were newly isolated in addition to deoxypodophyllotoxin (anthricin), anthriscusin, (-)-deoxypodorhizone, and anthriscinol methyl ether which were reported earlier as constituents of the root of this plant. From the CHCI3-soluble fraction of the ground part, deoxypodophyllotoxin, (-)-deoxypodorhizone, nemerosin, and falcarindiol were isolated. In vitro antiproliferative activities of the isolates against MK-1, HeLa, and B16F10 cells are reported.

Author information

Author/s: Ikeda, R (R); Nagao, T (T); Okabe, H (H); Nakano, Y (Y); Matsunaga, H (H); Katano, M (M); Mori, M (M);

Affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

Journal and publication information

Publication Type: Journal Article

Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)), published in JAPAN. (Language: eng)

Reference: 1998-May; vol 46 (issue 5) : pp 871-4

Dates: Created 1998/07/09; Completed 1998/07/09; Revised 2004/11/17;

PMID: 9621422, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antineoplastic Agents, Phytogenic - chemistry; pharmacology Apiaceae - chemistry Cell Division - drug effects Cell Line Enzyme-Linked Immunosorbent Assay Humans

Humans Magnetic Resonance Spectroscopy Plant Extracts - chemistry; pharmacology Plant Roots - chemistry Spectrophotometry, Ultraviolet Tumor Cells, Cultured

Associated Chemicals: Antineoplastic Agents, Phytogenic (0) ; Plant Extracts (0)

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