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| Research article summary (published 29 Jun 1998): |
Monitoring tumor activity in low grade glioma of childhood.
Full Abstract
Chemotherapeutic or radiotherapeutic regimens are being increasingly used in low grade glioma of childhood. These protocols require methods to monitor tumor activity. We report our experience in eleven patients. The tumors were localized in the optic pathway (3), cerebral cortex (4) and thalamus/hypothalamus (4). Histological diagnoses included low grade astrocytoma (6), gliofibroma (1) and ganglioglioma (2). Two children with neurofibromatosis type 1 (NF-1) and typical optical tumors were not biopsied. 13 episodes of progression were noted including 3 altered diagnoses. This was evident from clinical symptoms in 11/13 episodes, computed tomography (CT) or magnetic resonance imaging (MRI) in 10/13 situations, iodine-123-alpha-methyltyrosine (123I-IMT) single-photon emission computed tomography (SPECT) in 10/10 situations, fluorine-18 fluorodesoxyglucose (18F-FDG) positron emission tomography (PET) in 0/3 and thallium-201 (201Tl) SPECT in 1/1. Seven responses to chemotherapy were recorded. Clinical symptoms indicated this in 7/7 situations, MRI in 5/7, 123I-IMT SPECT in 1/2 and 201Tl SPECT in 1/1. These data suggest that 123I-IMT SPECT is a valuable addition to low grade glioma diagnostic and stress the need for a prospective study.
Author information
Author/s: Mölenkamp, G (G); Riemann, B (B); Kuwert, T (T); Sträter, R (R); Kurlemann, G (G); Schober, O (O); Jürgens, H (H); Wolff, J E (JE);
Affiliation: Department of Pediatric Oncology, University of Münster.
Journal and publication information
Publication Type: Journal Article
Journal: Klinische Pädiatrie (Klin Padiatr), published in GERMANY. (Language: eng)
Reference: -1998 Jul-Aug; vol 210 (issue 4) : pp 239-42
Dates: Created 1998/12/16; Completed 1998/12/16; Revised 2004/11/17;
PMID: 9743959, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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