A more flexible regression-to-the-mean model with possible stratification.

Full Abstract

We consider a regression-to-the-mean model that includes both additive and multiplicative treatment effects. We allow either or both of these treatment effects to be stratified by ranges of the first measurement. We focus on the situation where there is a very large sample on the first measurement and a relatively small subsample for the second measurement is selected, which often occurs in screening trials. We propose some asymptotically efficient estimators for the parameters of the model that are very simple to compute. We begin with a discussion of the full model, and more on tests and estimation for reduced models follows. An example from a large screening trial is discussed.

Author information

Author/s: Chen, S (S); Cox, C (C); Cui, L (L);

Affiliation: Department of Preventive Medicine, Rush-Presbytrian-St. Luke's Medical Center, Chicago, Illinois 60612-3824, USA. schen(-atsign-)bstat.pvm.rpslmc.edu

Journal and publication information

Publication Type: Journal Article

Journal: Biometrics (Biometrics), published in UNITED STATES. (Language: eng)

Reference: 1998-Sep; vol 54 (issue 3) : pp 939-47

Dates: Created 1998/11/03; Completed 1998/11/03; Revised 2007/11/15;

PMID: 9750243, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biometry - methods
Clinical Trials as Topic - statistics & numerical data
Humans
Hypercholesterolemia - blood; therapy

Hypercholesterolemia - blood; therapy
Mass Screening - statistics & numerical data
Models, Statistical
Regression Analysis

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a large map of 100+ related articles.