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| Research article summary (published 16 Sep 1998): |
A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.
Full Abstract
We identify a complex of three proteins in brain that has the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. The three proteins are: (1) CASK, a protein related to MAGUKs (membrane-associated guanylate kinases); (2) Mint1, a putative vesicular trafficking protein; and (3) Veli1, -2, and -3, vertebrate homologs of C. elegans LIN-7. CASK, Mint1, and Velis form a tight, salt-resistant complex that can be readily isolated. CASK, Mint1, and Velis contain PDZ domains in addition to other modules. However, no PDZ domains are involved in complex formation, leaving them free to recruit cell adhesion molecules, receptors, and channels to the complex. We propose that the tripartite complex acts as a nucleation site for the assembly of proteins involved in synaptic vesicle exocytosis and synaptic junctions.
Author information
Author/s: Butz, S (S); Okamoto, M (M); Südhof, T C (TC);
Affiliation: Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, 75235, USA.
Grants: R01-MH52804 (Agency:NIMH NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Cell (Cell), published in UNITED STATES. (Language: eng)
Reference: 1998-Sep; vol 94 (issue 6) : pp 773-82
Dates: Created 1998/10/13; Completed 1998/10/13; Revised 2007/11/15;
PMID: 9753324, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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