Research article summary (published 28 Oct 1998):

Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B and mGluR5b.

Full Abstract

We have studied the effects of single and repeated electroconvulsive shock (ECS) treatment on the mRNA levels of several glutamate receptors in the dentate gyrus and CA1 regions of the rat brain. In the dentate gyrus, such treatment elevated the mRNAs for the NMDA subunits NR2A and NR2B, but it reduced the mRNA for the metabotropic glutamate receptor mGlu5b. With the exception of NR2A, this effect was specific to the dentate gyrus. The changes in NR2B mRNA lasted the longest, but all changes had returned to control values after 48 h. The possible significance of such changes to the antidepressant effect of ECT is discussed. Copyright 1998 Elsevier Science B.V.

Author information

Author/s: Watkins, C J (CJ); Pei, Q (Q); Newberry, N R (NR);

Affiliation: Oxford University-SmithKline Beecham Centre for Applied Neuropsychobiology, University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, England, UK.

Journal and publication information

Publication Type: Journal Article

Journal: Brain research. Molecular brain research (Brain Res Mol Brain Res), published in NETHERLANDS. (Language: eng)

Reference: 1998-Oct; vol 61 (issue 1-2) : pp 108-13

Dates: Created 1999/06/10; Completed 1999/06/10; Revised 2003/11/14;

PMID: 9795172, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Anatomy, Cross-Sectional Animals Brain - metabolism Dentate Gyrus - chemistry Electroshock Hippocampus - chemistry In Situ Hybridization Long-Term Potentiation - physiology Male

Male Protein Isoforms - analysis; genetics; metabolism RNA, Messenger - analysis; biosynthesis Rats Rats, Sprague-Dawley Receptors, Glutamate - analysis; genetics Receptors, Metabotropic Glutamate - analysis; genetics Receptors, N-Methyl-D-Aspartate - analysis; genetics Time Factors

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Protein Isoforms (0) ; RNA, Messenger (0) ; Receptors, Glutamate (0) ; Receptors, Metabotropic Glutamate (0) ; Receptors, N-Methyl-D-Aspartate (0) ; metabotropic glutamate receptor 5 (0)

Related articles

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a larger map of 100+ related articles.