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| Research article summary (published 29 Sep 1998): |
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Acute allergic reaction and demonstration of specific IgE antibodies against alpha-1-protease inhibitor.
Full Abstract
A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum using an enzyme allergosorbent test. Because of the risk of further severe anaphylactic reaction, the replacement therapy with alpha1-PI was discontinued. Physicians should be aware of this rare complication.
Author information
Author/s: Meyer, F J (FJ); Wencker, M (M); Teschler, H (H); Steveling, H (H); Sennekamp, J (J); Costabel, U (U); Konietzko, N (N);
Affiliation: Ruhrlandklinik, Dept of Pneumology, University of Essen, Germany.
Journal and publication information
Publication Type: Case Reports; Journal Article
Journal: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology (Eur Respir J), published in DENMARK. (Language: eng)
Reference: 1998-Oct; vol 12 (issue 4) : pp 996-7
Dates: Created 1999/02/04; Completed 1999/02/04; Revised 2004/11/17;
PMID: 9817182, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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