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Electrophoretic and chromatographic patterns of glycosaminoglycans of the umbilical cord vessels and their alteration in EPH-gestosis.
Full Abstract
It was found that hyaluronic acid is the most abundant glycosaminoglycan (GAG) both in the umbilical cord arteries and in the umbilical cord veins. Chromatographic and as well as electrophoretic studies demonstrated that EPH-gestosis (Edema-Proteinuria-Hypertension), the most common pathological syndrome occurring in pregnancy, is accompanied by premature replacement of hyaluronic acid by sulphated GAGs in the investigated arteries but not in the veins. Such a replacement is a characteristic feature of the ageing process. One may conclude that EPH-gestosis is associated with a "premature ageing" of the umbilical cord arterial walls. The mechanism and possible role of this phenomenon in pathology are discussed.
Author information
Author/s: Romanowicz, L (L); Bankowski, E (E); Jaworski, S (S);
Affiliation: Department of Biochemistry, Medical Academy of Bialystok, Poland.
Journal and publication information
Publication Type: Journal Article
Journal: Acta biochimica Polonica (Acta Biochim Pol), published in POLAND. (Language: eng)
Reference: 1998-; vol 45 (issue 3) : pp 805-9
Dates: Created 1999/03/24; Completed 1999/03/24; Revised 2004/11/17;
PMID: 9918508, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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